Antibiotic Lek Amoxiclav - "Saved me in a matter of days! Very strong antibiotic Amoxiclav. How to take, what to expect. Dosage, full instructions and prescription from a doctor"

I thought I was dying. Almost everything that could have piled up:

  • Temperature 39
  • Chill that doesn't go away, even under all the blankets in the apartment. But what can I say, I had to go to the toilet wrapped in a blanket like a mummy, otherwise I thought that I would freeze on the spot. Don't ask how it was
  • I could not eat, I could not drink - it was difficult even to hold a spoon, my hands were shaking and wild weakness
  • There was no question of any TV - any noise caused a headache
  • Well, the cherry on the cake was a sore throat and a cough, like with a sore throat. Dry, wild, exhausting, persistent ... not letting you fall asleep. Fortunately, no runny nose. I think he would have finished me off
  • Had it happened now, I would have no doubt that the coronavirus is to blame. But the matter was long before, so it was out of the question.
... Intravenous administration of the drug is carried out using a syringe or system. The medicinal solution for them is prepared from powder and water for injection (for droppers, the finished composition is additionally mixed with saline) Injections and droppers can be prescribed only in hospital conditions with severe angina or if oral administration of the drug is impossible. The pediatric dose is calculated as 30 mg per kilogram of the patient's weight, and the frequency of administration, depending on the patient's condition, can vary from 2 to 4 times a day. Adults are prescribed 1200 mg three times a day.

✔️ HISTORY OF KNOWLEDGE WITH ANTIBIOTIC AMOXYCLAV

Naturally, she called a doctor.

The doctor came, listened, heard something and suggested probable bronchitis or pneumonia ... I was not in a position to take clarifying tests, so, as I understood, the doctor prescribed medications solely on the basis of my complaints and his assumptions and left a phone where you can urgently call if you get really sick.

✔️ AMOXICLAVE, PRICE

Amoxiclav price

Amoxiclav price

Amoxiclav tablets now cost about 400 rubles per pack of 14 tablets, which is equal to 30 rubles per pill (and 60 rubles per day of treatment).

I think this is an acceptable price.

✔️ AMOXICLAV FOR PNEUMONIA AND BRONCHITIS

... Intravenous administration of the drug is carried out using a syringe or system. The medicinal solution for them is prepared from powder and water for injection (for droppers, the finished composition is additionally mixed with saline) Injections and droppers can be prescribed only in hospital conditions with severe angina or if oral administration of the drug is impossible. The pediatric dose is calculated as 30 mg per kilogram of the patient's weight, and the frequency of administration, depending on the patient's condition, can vary from 2 to 4 times a day. Adults are prescribed 1200 mg three times a day.

As you can see in the instructions, no matter what I had - pneumonia or bronchitis, amoxiclav is prescribed in both cases. With angina, I did not see in the testimony that this antibiotic could be prescribed, but nevertheless I read in the reviews, which also helps in this case.

To relieve symptoms in my throat, I was prescribed as many as 3 drugs at once (they can be seen below.

✔️ AMOXICLAV, DOSAGE AND RECIPE

Here is the doctor's appointment. I was discharged to take amoxiclav 875 125 in exactly this dosage:

Amoxiclav dosage

Amoxiclav dosage

Amoxiclav recipe

Amoxiclav recipe

By the way, having studied the instructions, I realized that amoxiclav 875 + 125 could be replaced by 500 125, but only it would have to be taken more often - 3 times a day instead of 2 assigned to me. I will say right away that it would be inconvenient. Because taking amoxiclav tablets is better to combine with food, and in the state that I was, even two meals a day was a big question.

I had to take 14 Amoxiclav tablets.

As I understand it, this is a standard prescription, since one package of the antibiotic Amoxiclav is designed for this. 14 tablets per pack.

✔️ HOW TO TAKE AMOXICLAV BEFORE OR AFTER MEAL

The doctor didn’t tell me anything about this, and in vain. Because a patient with a temperature to look for this barely noticeable line in the instructions is still a pleasure. It took several revisions of it.

How to take Amoxiclav

How to take Amoxiclav

So, Amoxiclav should be taken correctly neither before or after meals, but with food. I took after the first two spoons.

✔️ AMOXICLAV, HOW MANY DAYS TO DRINK

If you look at the prescription prescribed by the doctor, then I was supposed to take Amoxiclav for 7 days, 2 times a day. The whole pack should have taken just the whole course (there are 14 tablets in it)

What does the instruction say about this:

Amoxiclav how many days to take

Amoxiclav how many days to take

It is permissible to take amoxiclav from 5 to 14 days. My doctor, apparently, decided to stick to the golden mean.

Further, setting the frequency of admission, she again followed the instructions and my ailment, apparently, was classified as "respiratory infections": 2 times a day. The interval between doses of Amoxiclav tablets was supposed to be 12 hours.

I took my first pill at 11 am. The second, accordingly, I tried to take at 23. Strictly adhering to such an interval was very difficult in the state in which I was. If you wanted to sleep, then I drank Amoxiclav earlier in time. And vice versa, she could oversleep and accept in the middle of the night.

But nevertheless, it worked as it should.

✔️ AMOXYCLAV, SIDE EFFECTS

The only side effect that the doctor warned me about was a mandatory stomach upset, and Linex was prescribed to prevent this.

In the instructions, the following side effects from Amoxiclav are allowed:

Amoxiclav side effects

Amoxiclav side effects

As for the gastrointestinal tract: I already had Linex, I didn't buy it on purpose. The day before the end of the course of admission, he ended and did not buy in addition. But I did not notice the difference. With Linex, that without him, everything was the same with the gastrointestinal tract. Perhaps because I tried to strictly adhere to the rule of taking Amoxiclav at the beginning of a meal. The instructions say that in this case, stomach problems can be avoided altogether and without additional measures.

✔️ AMOXICLAV, HOW MANY DAYS TO TAKE BEFORE THE EFFECT ONCE

I repeat once again - I had to take it for 7 days.

But amoxiclav turned out to be such a strong antibiotic that I felt relief almost immediately - on the second day. On the third day, the condition was the same as on the second, and on the third, all manifestations of the disease disappeared - both the temperature, and cough, and sore throat.

I felt so good that I stopped taking it even without the doctor's consent.

Amoxiclav when it helps

Amoxiclav when it helps

As you can see in the photo, 6 tablets were enough for me to recover, and this is only 3 days of taking.

✔️ AMOXYCLAV, POWERFUL ANTIBIOTIC OR NOT

Amoxiclav is the antibiotic that could surprise me.

I began to take it in such a state that it seemed to be dying. Therefore, I was sure that I would have to be treated for the prescribed 7 days, if not longer. I could not even think that amoxiclav would work the very next day of admission, and after 3 days I would feel so healthy that I would boldly cancel it.

Amoxiclav is a strong antibiotic or not

Amoxiclav is a strong antibiotic or not

It is worth making a remark here. This was my second or third antibiotic in my life, that is, I do not have the habit of throwing antibiotics with or without (I know that many people sin this way). Therefore, it is unlikely that I have resistance, which allowed Amoxiclav to act as quickly as possible.

✔️ AMOXYCLAV AND ALCOHOL, COMPATIBILITY

I know many people are interested in this issue. Although I have always known that antibiotics are not compatible with alcohol.

Strange, I did not find anything in the instructions on the compatibility of Amoxiclav and alcohol. Maybe she looked bad.

In any case, Amoxiclav is a penicillin-type drug, which means it is impossible. Definitely not. This reduces the effect of the antibiotic, can delay the treatment, put an extra burden on the body ...

✔️ AMOXICLAV, INSTRUCTIONS FOR USE

I have already shown individual parts of the instructions for the Amoxiclav tablets, here I have collected what was not included in the main part.

Amoxiclav, contraindications:

Amoxiclav contraindications

Amoxiclav contraindications

I highly recommend reading about interactions with other medications. It is important:

Amoxiclav interaction with alcohol

Amoxiclav interaction with alcohol

Special instructions:

Amoxiclav instruction

Amoxiclav instruction

And here, although I did not find anything important for myself, it may be useful to someone:

... Intravenous administration of the drug is carried out using a syringe or system. The medicinal solution for them is prepared from powder and water for injection (for droppers, the finished composition is additionally mixed with saline) Injections and droppers can be prescribed only in hospital conditions with severe angina or if oral administration of the drug is impossible. The pediatric dose is calculated as 30 mg per kilogram of the patient's weight, and the frequency of administration, depending on the patient's condition, can vary from 2 to 4 times a day. Adults are prescribed 1200 mg three times a day. ... Intravenous administration of the drug is carried out using a syringe or system. The medicinal solution for them is prepared from powder and water for injection (for droppers, the finished composition is additionally mixed with saline) Injections and droppers can be prescribed only in hospital conditions with severe angina or if oral administration of the drug is impossible. The pediatric dose is calculated as 30 mg per kilogram of the patient's weight, and the frequency of administration, depending on the patient's condition, can vary from 2 to 4 times a day. Adults are prescribed 1200 mg three times a day. ... Intravenous administration of the drug is carried out using a syringe or system. The medicinal solution for them is prepared from powder and water for injection (for droppers, the finished composition is additionally mixed with saline) Injections and droppers can be prescribed only in hospital conditions with severe angina or if oral administration of the drug is impossible. The pediatric dose is calculated as 30 mg per kilogram of the patient's weight, and the frequency of administration, depending on the patient's condition, can vary from 2 to 4 times a day. Adults are prescribed 1200 mg three times a day. ... Intravenous administration of the drug is carried out using a syringe or system. The medicinal solution for them is prepared from powder and water for injection (for droppers, the finished composition is additionally mixed with saline) Injections and droppers can be prescribed only in hospital conditions with severe angina or if oral administration of the drug is impossible. The pediatric dose is calculated as 30 mg per kilogram of the patient's weight, and the frequency of administration, depending on the patient's condition, can vary from 2 to 4 times a day. Adults are prescribed 1200 mg three times a day.

✔️ AMOKSIKLAV, ANALOGUES

Amoxiclav analogues

Amoxiclav analogues

There are a lot of them. The most famous analogue of Amoxiclav tablets is Augmentin. There is also Flemoklav (also a good manufacturer), Rapiklav, Panklav and a drug without an exact name from our dear Pharmstandard.

They all contain amoxicillin and clavulanic acid in their composition.

At the time of appointment, the doctor also admitted taking antibiotic analogues if Amoxiclav was not available. She advised to pay attention to the ending "clav" in the name, so that clavulanic acid was always present. But I was lucky - I bought exactly what was prescribed.

✔️ ANTIBIOTIC AMOXICLAV - MY REVIEW. TOTAL

Amoxiclav reviews

Amoxiclav reviews

I do not know if Amoxiclav helps with coronavirus or not (for many now this is an urgent question). But on the other hand, I know something else for sure: in my case, Amoxiclav proved to be a strong antibiotic, which helped 2 times faster than planned. Besides, I didn't get any side effects from him, not even a standard indigestion.

With a clear conscience, I can recommend. Naturally, only if prescribed by a doctor.

Features of taking Amoxiclav.

Amoxiclav is a common antibiotic used in pediatrics as well as for therapeutic purposes. However, there are a number of features of the use of this antibiotic. In this article, we'll show you how to take it.

Amoxiclav: composition and action

The composition of this medication contains directly an antibiotic of the penicillin group, as well as clavulanic acid. Why is this ingredient added in the manufacture of a medicine? The fact is that clavulanic acid improves penetration from the membranes and helps the antibiotic do its job better. The basis of the action of this substance is that it is introduced into the shells of bacteria and the synthesis of some amino acids and proteins stops. Due to this, bacteria molecules are destroyed, clavulanic acid improves interaction, as well as the penetration of the antibiotic into the intercellular membranes.

As for taking this remedy, there are many contraindications. The fact is that when taking the medication, it can very often manifest itself: dysbiosis, as well as thrush, the spread of fungi on the mucous membranes. Often found after taking antibiotics vaginal candidiasis, intestinal dysbiosis. In children, candidiasis or stomatitis is observed, which is provoked by the presence and growth of candida fungi on the mucous membranes of the mouth.

Medicine
Medicine

Amoksiklav: before or after meals to take?

In order to minimize the effect of the antibiotic on healthy cells and prevent the above situations from occurring, it is recommended to take it correctly. In order for this medicine to have a minimal effect on the state of health and intestinal flora, it is recommended to take antibiotics directly with food.

It is unacceptable to take them before meals, and also one hour after meals. Because at this time the intestines and stomach are half empty, which enhances the effect of the antibiotic and provokes the destruction of healthy microflora of the stomach and intestines. Accordingly, it is permissible to drink this medicine only with food intake.

Suspension
Suspension

Indications for the use of Amoxiclav

It should be noted that the antibiotic is effective against gram-positive and gram-negative bacteria.

Basically, this medicine is prescribed for the treatment of such pathologies:

  • Upper respiratory tract infections
  • Chronic rhinitis
  • Sinusitis
  • Abscess
  • Tonsillitis
  • Pharyngitis
  • In addition, it is used to treat the urinary tract and some infections in gynecology
  • It is advisable to use an antibiotic in the event of a bite by wild animals in order to prevent tissue infection
  • Prescribed for cholecystitis and cholangitis
Antibiotics
Antibiotics

Amoxiclav: interaction with other drugs

It should be noted that this antibiotic is quite effective and interacts with some substances and drugs, forming compounds harmful to health. Accordingly, it is worth taking this drug with caution with some of the drugs. Basically, you need to be very careful when using diuretics, as well as non-steroidal anti-inflammatory drugs.

The fact is that these substances increase the concentration of amoxicillin, while clavulanic acid remains in the same ratio. Accordingly, because of this, the effectiveness of the antibiotic decreases, but the number of contraindications increases. The risk of colpitis, as well as dysbiosis and candidiasis, increases.

Medicine
Medicine

Vitamin C, ascorbic acid increase the absorption of the antibiotic. Do not use the medicine with allopurinol, as this can cause severe allergic reactions in the form of skin rashes, trophic ulcers, and weeping wounds. Therefore, if you use any other medicines, you must use them separately from Amoxiclav. This medicine should be used only with food intake, and the rest 2 hours before or 2 hours after eating. Thus, it will be possible to minimize the negative effects of the antibiotic on the body.

Other antibiotics that are used together with Amoxiclav at the same time reduce its action. Accordingly, we recommend that you stop using other antibiotics for the period of treatment with Amoxiclav, because this can be harmful to health and increases the risk of side effects.

Pills
Pills

How to take Amoxiclav: dosage

Regarding the dosage, on average one tablet is prescribed, which contains 250 mg of the antibiotic, every 8 hours. Accordingly, you will have to take them 3 times a day. If there is a very severe infection, then it is prescribed 500 mg three times a day.

If the patient has impaired liver function, as well as kidney function, it is recommended to reduce the concentration, as well as the amount of antibiotic taken, depending on its clinical characteristics in the blood and urine. It is worth remembering that the drug is not prescribed for children under 12 years of age and weighing less than 40 kg.

Medicines
Medicines

Amoxiclav: contraindications

Usually the antibiotic is absorbed and absorbed well, but there are also contraindications for use, including allergies to penicillins and cephalosporins.

Contraindications:

  • You can not take the drug for jaundice, as well as more serious liver disorders. Because the drug increases the load on this organ.
  • Cannot be prescribed to patients with severe renal impairment.
  • The drug is not prescribed for children under 12 years of age, whose weight is less than 40 kg.
  • Also, the drug is contraindicated in infectious mononucleosis and lymphocytic leukemia.
  • It is worth using the medicine with caution during pregnancy and lactation. It has been established that the drug crosses the placenta and can provoke the development of serious developmental disorders in the fetus. Accordingly, this antibiotic is rarely prescribed for pregnant women.
  • You can not use the drug while breastfeeding, because a large amount of Amoxiclav is excreted in breast milk. In addition, traces of clavulanic acid were found in milk, but in small quantities. Despite this, it is prohibited to use the drug during lactation. You need to express milk and pour it out.

If you have colitis, then you should be prepared for the fact that it may worsen when taking an antibiotic. With diseases of the gastrointestinal tract, it is worth using the medicine with caution. Because very often an exacerbation of ulcers and gastritis is recorded.

As you can see, the antibiotic should be used with caution, taken with meals. This is a very important condition for its effectiveness, as well as for reducing the risks of developing side effects.

VIDEO: Amoxiclav

Amoxiclav

Amoxiclav

Indications for use

The drug is prescribed for bacterial infections caused by sensitive pathogens:

- upper respiratory tract infections (bronchitis, pneumonia, pleural empyema, lung abscess);

- infections of the ENT organs (sinusitis, tonsillitis, otitis media);

- infections of the biliary tract (cholangitis, cholecystitis);

- intestinal infections (dysentery, salmonellosis, salmonella carriage);

- infections of the genitourinary system and pelvic organs (pyelonephritis, pyelitis, cystitis, urethritis, prostatitis, cervicitis, salpingitis, salpingo-oophoritis, tubo-ovarian abscess, endometritis, bacterial vaginitis, septic abortion, postpartum sepsis, pelvioperitonitis, soft chancre);

- infections of the skin and soft tissues (erysipelas, impetigo, secondarily infected dermatoses, abscess, phlegmon, wound infection);

- osteomyelitis, endocarditis, meningitis, sepsis;

- peritonitis, postoperative infections, prevention of infections in surgery.

Possible analogs (substitutes)

Active ingredient, group

Dosage form

Powder for preparation of solution for intravenous administration

powder for oral suspension

film-coated tablets 250 mg + 125 mg, 500 mg + 125 mg, 875 mg + 125 mg

Contraindications

- hypersensitivity (including to cephalosporins and other beta-lactam antibiotics);

- cholestatic jaundice and other liver dysfunctions caused by a history of taking the drug;

- infectious mononucleosis and lymphocytic leukemia;

- children under 12 years of age or weighing up to 40 kg (for coated tablets).

Use with caution during pregnancy and lactation, in patients with severe liver failure, gastrointestinal diseases (including a history of colitis associated with the use of penicillins), chronic renal failure.

How to use: dosage and course of treatment

Film-coated tablets - inside, at the beginning of a meal. The dosage regimen is set individually, depending on the age, body weight, kidney function of the patient, as well as the severity of the infection.

The course of treatment is 5-14 days. The duration of the course of treatment is determined by the attending physician. Treatment should not continue for more than 14 days without a second medical examination.

For children under 12 years of age, the dose is prescribed depending on age and body weight. The recommended dosing regimen is 40 mg / kg / day in 3 divided doses.

Children weighing 40 kg or more should be given the same doses as adults. For children under the age of 6 years, it is more preferable to take a suspension of the drug.

For adults and children over 12 years of age (or> 40 kg of body weight), the usual dose in the case of mild to moderate infection is 1 table. 250 + 125 mg every 8 hours or 1 table. 500 + 125 mg every 12 hours, in case of severe infection and respiratory tract infections - 1 table. 500 + 125 mg every 8 hours or 1 table. 875 + 125 mg every 12 hours

For odontogenic infections, the drug is prescribed in 1 table. 250 + 125 mg every 8 hours or 1 table. 500 + 125 mg every 12 hours for 5 days.

In patients with impaired renal function, dose adjustment is based on the maximum recommended dose of amoxicillin and is carried out taking into account the values ​​of Cl creatinine.

The drug in powder for the preparation of a suspension for oral administration is administered orally. The daily dose of suspensions 125 + 31.25 mg / 5 ml and 250 + 62.5 mg / 5 ml (to facilitate correct dosing, a dosing pipette is inserted into each package of suspensions 125 + 31.25 mg / 5 ml and 250 + 62.5 mg / 5 ml, graduated to 5 ml, with a graduation scale of 0.1 ml or a dosage spoon with a capacity of 5 ml, with ring marks in the cavity for 2.5 and 5 ml).

Newborns and children under 3 months - 30 mg / kg / day (for amoxicillin), divided into 2 doses (every 12 hours).

Children older than 3 months - from 20 mg / kg for infections of mild and moderate severity up to 40 mg / kg for severe infections and infections of the lower respiratory tract, otitis media, sinusitis (according to amoxicillin) per day, divided into 3 doses (every 8 h).

The daily dose of the drug in suspension of 400 mg + 57 mg / 5 ml is calculated per kg of body weight, depending on the severity of the infection. From 25 mg / kg - for infections of mild and moderate severity up to 45 mg / kg - for severe infections and infections of the lower respiratory tract, otitis media, sinusitis (in terms of amoxicillin) per day, divided into 2 doses. To facilitate correct dosing, a dosing pipette is included in each package of the 400 mg + 57 mg / 5 ml suspension, graduated simultaneously in 1, 2, 3, 4, 5 ml and in 4 equal parts. Suspension 400 mg + 57 mg / 5 ml is used in children older than 3 months.

The exact daily doses are calculated based on the child's body weight.

The maximum daily dose of amoxicillin is 6 g for adults, 45 mg / kg for children.

The maximum daily dose of clavulanic acid (in the form of potassium salt) is 600 mg for adults and 10 mg / kg for children.

In patients with impaired renal function, the dose should be adjusted based on the maximum recommended dose of amoxicillin.

Patients with Cl creatinine> 30 ml / min do not require any dose adjustment.

Adults and children weighing more than 40 kg (the indicated dosage regimen is used for moderate and severe infections)

Patients with Cl creatinine 10-30 ml / min - 500/125 mg 2 times a day.

When Cl creatinine is <10 ml / min, the recommended dose is 500/125 mg once a day.

For patients on hemodialysis, the recommended dose is 500/125 mg every 24 hours, plus 500/125 mg during dialysis and another dose at the end of dialysis (because serum concentrations of amoxicillin and clavulanic acid are reduced).

Children weighing less than 40 kg

When Cl creatinine is 10-30 ml / min, the recommended dose is 15 / 3.75 mg / kg 2 times a day (maximum 500/125 mg 2 times a day).

When Cl creatinine is <10 ml / min, the recommended dose is 15 / 3.75 mg / kg once a day (maximum 500/125 mg).

For hemodialysis, the recommended dose is 15 / 3.75 mg / kg once a day. Before hemodialysis - 15 / 3.75 mg / kg. To restore the appropriate concentrations of the drug in the blood, it is necessary to take another dose of 15 / 3.75 mg / kg after hemodialysis.

The course of treatment is 5-14 days. The duration of the course of treatment is determined by the attending physician. Treatment should not continue for more than 14 days without a second medical examination.

Powder for preparation of solution for intravenous administration

Children: weighing less than 40 kg - the dose is calculated depending on the body weight.

Younger than 3 months with a body weight of less than 4 kg - 30 mg / kg every 12 hours.

Younger than 3 months with a body weight of more than 4 kg - 30 mg / kg every 8 hours.

In children under 3 months of age, the drug should be administered only slowly by infusion over 30-40 minutes.

Children from 3 months to 12 years old - 30 mg / kg with an interval of 8 hours, in case of a severe course of infection - with an interval of 6 hours.

Children with impaired renal function

The dose adjustment is based on the maximum recommended dose of amoxicillin. For patients with creatinine Cl values ​​above 30 ml / min, dose adjustment is not necessary.

Adults and children over 12 years old or weighing more than 40 kg - 1.2 g of the drug (1000 + 200 mg) with an interval of 8 hours, in case of a severe course of infection - with an interval of 6 hours.

Prophylactic doses for surgical interventions: 1.2 g with induction of anesthesia (with an operation duration of less than 2 hours). For longer operations - 1.2 g up to 4 times during the day.

For patients with renal impairment, the dose and / or the interval between injections of the drug should be adjusted depending on the degree of impairment.

The course of treatment is 5-14 days. The duration of the course of treatment is determined by the attending physician. With a decrease in the severity of symptoms, it is recommended to switch to oral forms of the drug to continue therapy.

pharmachologic effect

Combined preparation of amoxicillin and clavulanic acid - a beta-lactamase inhibitor. Acts bactericidal, inhibits the synthesis of the bacterial wall.

It is active against aerobic gram-positive bacteria (including strains producing beta-lactamases): Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes, Streptococcus anthracis, Streptococcus pneumoniae, Streptococcusterium viridans, Enterococcus monoccus faeppocycalis anaerobic gram-positive bacteria: Clostridium spp., Peptococcus spp., Peptostreptococcus spp .;

aerobic gram-negative bacteria (including strains producing beta-lactamases): Escherichia coli, Proteus mirabilis, Proteus vulgaris, Klebsiella spp., Salmonella spp., Shigella spp., Bordetella pertussis, Yersinia enterocolitica, Gardnereseralla vaginalis, Neisella mexeriae, Neisisella vaginalis catarrhalis, Haemophilus influenzae, Haemophilus ducreyi, Yersinia multocida (formerly Pasteurella), Campylobacter jejuni;

anaerobic gram-negative bacteria (including strains producing beta-lactamases): Bacteroides spp., including Bacteroides fragilis.

Clavulanic acid inhibits types II, III, IV and V beta-lactamases, is inactive against type I beta-lactamases produced by Enterobacter spp., Pseudomonas aeruginosa, Serratia spp., Acinetobacter spp. Clavulanic acid has a high tropism for penicillinases, due to which it forms a stable complex with the enzyme, which prevents the enzymatic degradation of amoxicillin under the influence of beta-lactamases.

Side effects

According to the WHO, undesirable effects are classified according to their frequency of development as follows: very often (≥ 1/10), often (≥1 / 100, <1/10), infrequently (≥1 / 1000, <1/100), rarely (≥1 / 10000, <1/1000) and very rarely (<1/10000); the frequency is unknown (the frequency of occurrence of the events cannot be determined from the available data).

Infectious and parasitic diseases: often - candidiasis of the skin and mucous membranes; the frequency is unknown - an increase in the resistance of microorganisms.

Blood and lymphatic system disorders: rarely - reversible leukopenia (including neutropenia), thrombocytopenia; the frequency is unknown - eosinophilia, thrombocytosis, reversible agranulocytosis, an increase in bleeding time and an increase in prothrombin time, anemia (including reversible hemolytic anemia).

Immune system disorders: frequency unknown - angioedema, anaphylactic reactions, allergic vasculitis, a syndrome similar to serum sickness.

Nervous system disorders: infrequently - dizziness, headache; frequency unknown - convulsions (can occur in patients with impaired renal function, as well as when taking high doses of the drug), reversible hyperactivity, aseptic meningitis, anxiety, insomnia, change in behavior, agitation.

Disturbances from the gastrointestinal tract: very often - diarrhea; often - nausea, vomiting. Nausea is most commonly seen with ingestion of high doses. If, after the start of taking the drug, there are undesirable reactions from the gastrointestinal tract, they can be eliminated if the drug is taken at the beginning of a meal.

Uncommon - indigestion; very rarely - gastritis, stomatitis; frequency unknown - antibiotic-associated colitis (including hemorrhagic colitis and pseudomembranous colitis), black hairy tongue,

Liver and biliary tract disorders: infrequently - increased activity of alanine aminotransferase (ALT) and / or aspartate aminotransferase (AST). These reactions have been observed in patients receiving beta-lactam antibiotic therapy, but their clinical significance is unknown. Very rare: an increase in the activity of alkaline phosphatase and an increase in the concentration of bilirubin in the blood plasma; frequency unknown: cholestatic jaundice, hepatitis.

Violations of the skin and subcutaneous tissues: infrequently - skin rash, pruritus, urticaria; rarely - erythema multiforme exudative; frequency unknown - Stevens-Johnson syndrome, toxic epidermal necrolysis, bullous exfoliative dermatitis, acute generalized exanthematous pustulosis, drug rash with eosinophilia and systemic symptoms (DRESS syndrome).

Renal and urinary tract disorders: frequency unknown - crystalluria, interstitial nephritis, hematuria.

Overdose

Symptoms: gastrointestinal disorders (abdominal pain, diarrhea, vomiting) and disturbances in water and electrolyte balance. There have been reports of the development of crystalluria caused by taking amoxicillin, which in some cases led to the development of renal failure.

Seizures may develop in patients with renal insufficiency or in patients receiving high doses of the drug.

In case of an overdose, the patient should be under medical supervision, treatment is symptomatic.

In the case of a recent intake (less than 4 hours), it is necessary to lavage the stomach and prescribe activated charcoal to reduce absorption.

Amoxicillin / clavulanic acid is removed by hemodialysis.

special instructions

During the course of treatment, it is necessary to monitor the state of the function of the hematopoietic organs, liver and kidneys.

In order to reduce the risk of side effects from the gastrointestinal tract, the drug should be taken with meals.

The development of superinfection is possible due to the growth of microflora insensitive to it, which requires a corresponding change in antibiotic therapy.

When prescribed to patients with sepsis, the development of a bacteriolysis reaction (Jarisch-Herxheimer reaction) is possible.

In patients with hypersensitivity to penicillins, cross-allergic reactions with cephalosporin antibiotics are possible.

Since tablets - combinations of amoxicillin and clavulanic acid of 250 and 500 mg contain the same amount of clavulanic acid (125 mg), 2 tablets of 250 mg are not equivalent to 1 tablet of 500 mg.

Application during pregnancy and lactation

Animal studies have not revealed data on the dangers of taking the drug during pregnancy and its effect on the embryonic development of the fetus.

During pregnancy and lactation, the drug is used only if the intended benefit to the mother outweighs the potential risk to the fetus and child.

Small amounts of amoxicillin and clavulanic acid pass into breast milk.

Infants receiving breastfeeding may develop sensitization, diarrhea, candidiasis of the oral mucous membranes. When taking the drug, it is necessary to decide on the termination of breastfeeding.

Interaction

Amoxiclav and aminoglycoside antibiotics are chemically incompatible.

Do not mix in a syringe or infusion bottle with other drugs.

It is necessary to avoid mixing with solutions of dextrose, dextran, sodium bicarbonate, as well as with solutions containing blood, proteins, lipids.

Antacids, glucosamine, laxatives drugs, aminoglycosides slow down and reduce absorption; ascorbic acid enhances absorption.

Bactericidal antibiotics (including aminoglycosides, cephalosporins, cycloserine, vancomycin, rifampicin) have a synergistic effect; bacteriostatic drugs (macrolides, chloramphenicol, lincosamides, tetracyclines, sulfonamides) - antagonistic.

The use of the drug increases the effectiveness of indirect anticoagulants (suppressing the intestinal microflora, reduces the synthesis of vitamin K and the prothrombin index). With the simultaneous administration of anticoagulants, it is necessary to monitor the indicators of blood clotting.

Reduces the effectiveness of oral contraceptives, drugs, in the process of metabolism of which PABA is formed, ethinylestradiol - the risk of bleeding "breakthrough".

Diuretics, allopurinol, phenylbutazone, NSAIDs, etc. Drugs that block tubular secretion increase the concentration of amoxicillin (clavulanic acid is excreted mainly by glomerular filtration).

Allopurinol increases the risk of skin rashes.

Storage conditions

In its original packaging at a temperature not exceeding 25 ° C.

The finished suspension is stored at 2-8 ° C in a tightly closed bottle.

Keep out of the reach of children.

Shelf life

Film-coated tablets - 2 years.

Powder for preparation of solution for intravenous administration - 2 years.

Powder for preparation of oral suspension - 2 years. Ready suspension - 7 days.

Do not use after the expiration date printed on the package.

Questions, answers, reviews on the drug Amoxiclav

03/04/2020

The child's cough does not go away, we are already undergoing the third treatment, mostly coughs at night and calms down only after taking drops

Zodak

from allergies, I can't understand what he is reacting to, or does he still have an illness, first they drank a course of amoxicillin, Althea syrup, it did not help, then they passed it on to me

cephalexin

suspension and

lazolvan

, also did not help, now they prescribed

Bromhexine Syrup

, Amoxiclav,

Ambroxol

for inhalation and left Zodak. I'm afraid the treatment will turn out sideways for us. Help.

Hello.

There are absolutely not enough data to assess the child's condition, however, this cannot be done in absentia. The reason for prescribing antibiotics is also unclear. In this case, giving instructions at random means putting the patient in danger, especially the child. It is necessary to clearly understand the reason for what is happening, judging by your story, it has not been finally clarified. It is necessary to provide a personal examination of the child by a good pediatric allergist, as well as a pulmonologist, infectious disease specialist and, possibly, an immunologist.

03/22/2019

Hello.

I am interested in drug compatibility

simvastatin

, amoxiclav and

eutirox

with daily use. Thank.

Hello.

The antibiotic Amoxiclav cannot be used for a long time every day, it is used for a limited time, determined by the patient's attending physician. Simvastatin and Eutirox, if indicated, can indeed be used for a long time. Any of these drugs can only be used on the personal prescription of the attending physician. The simultaneous use of these drugs for a reasonable prescription by a physician is permissible.

02/20/2017

с

Is it possible to take amoxiclav,

?

metronidazole

Afobazole

Hello.

It is possible, subject to normal portability. But Amoxiclav and Metronidazole can only be used according to the personal prescription of the attending physician.

12/19/2016

Good day!

Can you please tell me if it is possible to take Amoxiclav (625 mg, 1 tablet 3 times a day) during pregnancy at 19 weeks? In the urine, leukocytes and protein are increased against the background of chronic pyelonephritis.

Thank you!

Hello.

This drug can be used during pregnancy only on the personal prescription of the attending physician, if the expected benefit to the mother from taking Amoxiclav outweighs the potential risk to the unborn child. This is determined by the doctor and only personally.

However, even without pregnancy, any antibiotics should be taken only as directed by a doctor.

12.09.2016

Hello.

for the treatment of urogenital infections, the doctor prescribed Amoxiclav and

* Wilprafen

simultaneously 3 times a day. But the instructions say that these antibiotics reduce the effectiveness of each other. Is it right to drink them together, or is it better to take turns - first drink oldin, then the second? Or can it be spread by the time of admission?

What would you advise in this situation /

  • Thank!
  • Hello.
  • Indeed, these drugs are undesirable to take together. If you act correctly, then you should draw the attention of the doctor who prescribed the treatment, and follow his instructions. Theoretically, it would be possible to "drink" one drug first, and then proceed to taking the second, but only the attending physician personally has the right to give specific instructions, such rules regarding the appointment of such drugs.

Ask your question to a specialist "

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Pills Since angina is considered a multifaceted pathology and can proceed in different forms, there can be no talk of universal prescriptions of the antibiotic "Amoxiclav". Something depends on the shape of the sore throat. So, with catarrhal sore throat "Amoxiclav" and other effective antibiotics are not always required. With a mild form of the disease, doctors limit themselves to prescribing abundant drinking, antiseptics and thermal procedures (at low temperatures).

"Amoxiclav" in case of catarrhal sore throat, an adult patient or a child can be prescribed in the presence of such threatening symptoms as:

high body temperature, which lasts for at least 3 days (meaning a temperature of 38 degrees, lower temperatures indicate that the body is fighting the disease on its own and quite successfully),

the appearance of a light plaque on the tonsils, which indicates the transition of the disease to a more severe form, and any complications are associated with the addition of a bacterial infection, even if initially there was no talk about it,

an increase in the submandibular lymph nodes, which indicates an inflammatory factor and is fraught with the spread of infection throughout the body.

But with a lacunar, follicular and purulent form of angina, antibiotics cannot be dispensed with, because dangerous symptoms are usually present at the very beginning of the disease. And the drug "Amoxiclav" for angina is preferred by many experienced doctors, especially if amoxicillin is prescribed to a person for the first time due to infectious pathologies. It should be understood that with subsequent appointments, doctors will prefer drugs with other active ingredients in order to avoid the development of addiction to the drug in bacteria.

The dosage regimen of an antibiotic based on amoxicillin and clavuonic acid depends not only on the form of angina and the patient's well-being, but also on the age, and in some cases on the patient's weight.

Consider the method of administration and dose of the drug that are recommended in the instructions for use of the drug.

... As for the usual "Amoxiclav" tablets, it is recommended to take them with meals (preferably at the very beginning of the meal). The tablets do not need to be crushed, they are swallowed whole and washed down with water. Tablets "Amoxiclav" 375 mg are intended for the treatment of adults and children. Children are recommended to give pills no earlier than 6 years.

For small patients under 12 years of age or before reaching a weight of 40 kg, the dosage is calculated as 40 mg per 1 kg of the child's weight. It is recommended to give the medicine in the received dosage to the child 3 times a day.

Patients weighing more than 40 kg are prescribed medication for a mild form of pathology at a dosage of 375 mg. You need to take the drug in this dosage every 8 hours, i.e. 2-3 times a day.

For patients with moderate angina, the preferred dosage is 625 mg, so you need to purchase the appropriate drug and take it 1 tablet at intervals of 12 hours. The drug 250/125 mg is also suitable for treatment, but it will already be necessary to take it 3 times a day, 1 tablet with an eight-hour interval between doses.

In a severe form of the disease, drugs are prescribed 625 or 1000 mg. The first will have to be taken 1 tablet three times, the second - twice a day.

Tablets "Amoxiclav Kviktab", like "Amoxiclav" with an increased dosage, are also intended for adult patients. They are taken only by those patients whose weight is over 40 kg.

The dosage regimen of soluble tablets is identical to the dosage and frequency of administration of conventional tablets of 625 and 1000 mg, respectively. But the method of application is somewhat different. The tablets can be sucked, chewed or dissolved in water (half a glass), after which the resulting suspension is drunk.

Suspension for oral administration.

"Amoxiclav" for angina in children under 6 years of age is prescribed mainly in the form of oral suspension, which contains small concentrations of active substances. The effective dosage of the drug in the form of a suspension is calculated according to the weight of the child.

For newborns up to 2 months of age, the suspension can be prescribed in a daily dosage of not more than 30 mg for each kilogram of the baby's weight. For children about 2 months to 2 years old, the daily dose can be increased to 40 mg per 1 kg of body weight. For children over 2 years old, whose body weight does not exceed 40 kg, the daily dose, depending on the severity of the pathology, can range from 20 to 60 mg per kilogram of the child's weight. In this case, the proportion of clavuonic acid per kilogram of the child's weight will not exceed 15 mg. With a weight of 40 kg, this would be 600 mg, which is considered the daily maximum for adults.

The calculated dose, depending on the doctor's prescription, will need to be divided into 2 or 3 doses. The intervals between doses (8 or 20 hours) must be observed as precisely as possible.

The suspension can also be treated in adults, but given the low dosage of the drug, it is advisable to use it only with a mild course of angina. The adult dosage of powder for suspension is 500 mg three times a day, i.e. only 1500 mg.

When we talked about dosage, the suspension was not about the finished product, but about the ampicillin content in the amount of powder that is needed to prepare the specified dose. But each time there is no need to prepare a single dose separately. The powder is mixed with water immediately in a bottle, adding liquid in 2 doses and constantly shaking the tube so that the compositions are evenly mixed. As a result, you get 100 ml of the finished drug (suspension).

The package with the drug should contain a special dosing syringe or measuring spoon, 5 ml. Based on the dosage indicated on the package, 5 ml of the suspension will contain 125 or 250 mg of amoxicillin.

Usually, patients do not need to calculate how much medication they will have to drink in terms of ampicillin. The doctor prescribes the drug, indicating clearly the number of spoons or the volume of the suspension that you need to drink in 1 dose. With a mild course of the disease, the child is usually prescribed 5 ml of a ready-made suspension containing 125 mg of amoxicillin and 31.25 mg of clavuanate. If the disease progresses in a more severe form, the doctor may prescribe a drug with an increased dosage containing 250 mg of amoxicillin in the same 5 ml of suspension.

The suspension, like the tablets, is taken during meals, at the very beginning, that is, immediately before meals.

The dropper is put on for 30-40 minutes. In this case, a freshly prepared injection or infusion solution must be used within 20 minutes, after which it becomes unusable and must be disposed of.Powder for injection

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